It is very important that your doctor check your progress at regular visits to make sure this medicine is working properly and to check for unwanted effects. If you have trouble sleeping (insomnia), do not take this medicine too close to bedtime. A part of the extended-release tablet may pass into your stool. Swallow the extended-release tablet, sustained-release tablet, and tablet whole. Use only the brand of this medicine that your doctor prescribed. This medicine is available only with your doctor’s prescription.
What factors can affect my dosage?
Wellbutrin XL is an antidepressant used to treat major depressive disorder and seasonal affective disorder. The Zyban brand of bupropion is used to help people stop smoking by reducing cravings and other withdrawal effects. Bupropion is indicated for the treatment of major depressive disorder (MDD), seasonal affective disorder (SAD), and as an aid to smoking cessation. This medicine may cause seizures, especially in people with certain medical conditions or when using certain drugs. Tell your doctor about all of your medical conditions and the drugs you use. You should not take bupropion if you have seizures, an eating disorder, or suddenly stopped using alcohol, seizure medication, or sedatives.
Digestive side effects, including constipation and nausea
The following adverse reactions have been identified during post-approval use of WELLBUTRIN and are not described elsewhere in the label. Because these reactions are reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure. Discontinue WELLBUTRIN and do not restart treatment if the patient experiences a seizure.
What are the serious side effects of Wellbutrin?
This is not a complete list of side effects, and others may occur. You are encouraged to report negative side effects of prescription drugs to the FDA. These include people who have (or have a family history of) bipolar illness (also called manic-depressive illness) or suicidal thoughts or actions. Depression or other serious mental illnesses are the most important causes of suicidal thoughts and actions.
Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements. Drinking alcoholic beverages should be limited or avoided, if possible, with bupropion. Serious skin reactions (eg, Stevens-Johnson syndrome) can occur with this medicine.
- It is important to discuss the risks and benefits of treatment with your doctor and caregivers.
- The recommended starting dose is 200 mg/day, given as 100 mg twice daily.
- This is not a complete list of side effects, and others may occur.
- Antidepressants increased the risk of suicidal thoughts and behavior in children, adolescents, and young adults in short-term trials.
- This is because both forms of the drug have the same active ingredient, which is bupropion.
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This copyrighted material has been downloaded from a licensed data provider and is not for distribution, except as may be authorized by the applicable terms of use. Psychiatric/medical checkups or tests such as blood pressure monitoring may be performed periodically to monitor your progress or check for side effects. This medication may interfere with certain medical/lab tests (such as brain scan for Parkinson’s disease, urine screening for amphetamines), possibly causing false test results.
Data from epidemiological studies of pregnant women exposed to bupropion in the first trimester indicate no increased risk of congenital malformations overall. All pregnancies, regardless of drug exposure, have a background rate of 2% to 4% for major malformations, and 15% to 20% for pregnancy loss. WELLBUTRIN should be used during pregnancy how long does a crack high last only if the potential benefit justifies the potential risk to the fetus. In this trial, 6.1% of subjects treated with the combination of sustained-release bupropion and NTS had treatment‑emergent hypertension compared with 2.5%, 1.6%, and 3.1% of subjects treated with sustained-release bupropion, NTS, and placebo, respectively.
Some people taking bupropion have severe high blood pressure, especially when using a nicotine replacement product (patch or gum). Your blood pressure may need to be checked before and during treatment with this medicine. You should not change your dose or stop using bupropion suddenly unless you have a seizure while taking this medicine. Stopping suddenly can cause unpleasant withdrawal symptoms. It may take 4 weeks or longer before you feel the full benefit of this medicine. Do not stop taking this medicine without talking to your doctor.
However, the fraction of the oral dose of bupropion excreted unchanged was only 0.5%, a finding consistent with the extensive metabolism of bupropion. Tell your healthcare provider if ambien and alcohol: side effects and overdose risk you are breastfeeding or plan to breastfeed while taking this medicine. Talk to your healthcare provider about the best way to feed your baby during treatment with this medicine.
Kyle struggled with depression for most of his life, but when his girlfriend encouraged him to seek treatment, he knew it was time to get the help he needed… Brightside Health can offer help for a full spectrum of conditions and severity levels. When you begin taking Wellbutrin, you should carefully follow your provider’s instructions alongside any instructions that come along with the medication itself. With Brightside, you have unlimited access to the care you need, including precision prescribing, psychiatry and therapy experts, and science-backed approaches that can help you feel like yourself again. Depression can be difficult, but Brightside is here to get you the care you deserve, whether that’s therapy, medication, or a combination of both.
Lifetime carcinogenicity studies were performed in rats and mice at bupropion doses up to 300 and 150 mg per kg per day, respectively. These doses are approximately 7 and 2 times the MRHD, respectively, on a mg per m2 basis. how to avoid a relapse when things seem out of control In the rat study there was an increase in nodular proliferative lesions of the liver at doses of 100 to 300 mg per kg per day (approximately 2 to 7 times the MRHD on a mg per m2 basis); lower doses were not tested.
Increases in dose should not exceed 100 mg/day in a 3-day period. You may have a higher risk of seizures if you use certain other medicines while taking Wellbutrin. Do not use an MAO inhibitor within 14 days before or 14 days after you take bupropion.
Use extreme caution when coadministering WELLBUTRIN with other drugs that lower seizure threshold (e.g., other bupropion products, antipsychotics, antidepressants, theophylline, or systemic corticosteroids). Use low initial doses and increase the dose gradually [see Contraindications (4), Warnings and Precautions (5.3)]. Antidepressants increased the risk of suicidal thoughts and behavior in children, adolescents, and young adults in short-term trials.
Bupropion is administered orally as a hydrochloride salt. Bupropion Tablets are available as regular or extended-release forms. There is no other route besides oral for bupropion administration. The kidneys of older adults may not work as well as they used to.
